End repair rewrites DNA. TrueLink™ preserves it.
Protect native templates, retain real biology, and reduce sequencing costs.
PROBLEM STATEMENT
End-repair based NGS library prep rewrites template DNA: erasing real biology; creating artificial errors; and failing to capture mixed template populations.
IMPACT
True mutations disappear
Synthetic errors introduced
Unusable molecules (chimeras) emerge
Native terminal structure destroyed
Single-stranded molecules drop out
Epigenetic signals lost
TECHNOLOGY
TrueLink™ - Library prep without compromise.
TrueLink™ leverages proprietary enzymes and adaptors in a unique, simultaneous dual-ligation workflow where sequencing adaptors attach directly to the native termini. No writing, no erasing, no splints, and no lost signals.
TrueLink™ safeguards every DNA molecule, unveiling true genomic insights.
Contact us
A novel NGS library preparation method that preserves and reveals the native ends
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PRODUCTS
DISTAL-seq
Increasingly rich and sensitive assays such as liquid biopsy and methylation sequencing have the potential to improve cancer detection.
However, the end repair and A-tailing (ER/AT) steps in virtually all sequencing library prep introduce mutations and obscure methylation at fragment termini, compromising clinical sequencing reliability, especially in sensitive applications like minimal residual disease (MRD) detection.
DISTAL-methyl-seq
Increasingly rich and sensitive assays such as liquid biopsy and methylation sequencing have the potential to improve cancer detection.
However, the end repair and A-tailing (ER/AT) steps in virtually all sequencing library prep introduce mutations and obscure methylation at fragment termini, compromising clinical sequencing reliability, especially in sensitive applications like minimal residual disease (MRD) detection.
ABOUT CANAL BIOSCIENCES
Canal Biosciences is advancing genomics through improved DNA library preparation technologies.
Our proprietary TrueLink™ platform preserves DNA template integrity, increasing genomic data accuracy while improving the efficiency and economics of DNA sequencing.
Our mission: Deliver best in class library prep workflows to power the high-precision NGS applications of the future.
Rooted in Lowell’s iconic canal district, Canal Biosciences carries forward Massachusetts’ legacy of turning industrial ingenuity into modern biotechnology.
MEET THE CANAL TEAM
Yu
Zheng
Founder & Co-CEO
Chris
Benoit
Co-CEO
Jason
Quagliata
Commercial Director
Jack
Percoskie
CFO
Matt
Hims
VP of R&D
Gary
Teeters
